หมอที่เชสเทนถูกรายล้อมไปด้วยกฎและหมอหน้าใหม่ เมื่อเรดร็อคเมาน์เทนเมดิคอลเข้ามาควบคุมโรงพยาบาล คอนราดพบว่าตัวเองตกอยู่ในสถานการณ์อันตรายเมื่อ…

Main
Matt Czuchry as Conrad Hawkins: a senior resident internist at Chastain Park Memorial Hospital and later chief resident. In season 3, he also gets a job as the team doctor for Georgia Revolution FC.
Emily VanCamp as Nic Nevin: a nurse practitioner at Chastain Park Memorial Hospital
Manish Dayal as Devon Pravesh: a second-year resident internist at Chastain Park Memorial Hospital
Shaunette René e Wilson as Mina Okafor: a surgical resident at Chastain Park Memorial Hospital. She is very intelligent and does not care for anyone's opinion, which AJ Austin seems to find intriguing.
Bruce Greenwood as Randolph Bell: Chief of Surgery, later CEO, at Chastain Park Memorial Hospital. He gets demoted from both positions in season 3 by Red Rock.
Moran Atias as Renata Morali (season 1): head of publicity at Chastain Park Memorial Hospital
Merrin Dungey as Claire Thorpe (season 1): former CEO at Chastain Park Memorial Hospital
Melina Kanakaredes as Lane Hunter (season 1, special guest season 2): a former oncologist at Chastain Park Memorial Hospital. She also owned her own medical clinics.
Malcolm-Jamal Warner as AJ The Raptor Austin (season 2–present, recurring season 1):[13] a cardiothoracic surgeon who joins Chastain Park Memorial Hospital at Bell's and Okafor's urging
Glenn Morshower as Marshall Winthrop (season 2 recurring seasons 1 & 3):[13] Conrad's father and the former chairman of the board at Chastain Park Memorial Hospital now the CEO of QuoVadis
Jane Leeves as Kitt Voss (season 2–present):[14] an orthopaedic surgeon
Morris Chestnut as Barrett Cain (season 3):[15] a neurosurgeon, promoted by Red Rock to Chief of Surgery after they demote Bell.



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