ในปี ค.ศ 1925 (พ.ศ.2468) เกิดการระบาดของโรคคอตีบสร้างความอลม่านขึ้นใน เมืองโนม รัฐอะแลสกา ไวรัสส่วนใหญ่ทำให้เด็ก ๆ ในเมืองเดือดร้อน ในขณะที่เซรุ่มที่ใช้รักษาโรคนี้อยู่ห่างเกือบ 700 ไมล์ มิหนำซ้ำในสภาวะหน้าสิ่วหน้าขวานดันเกิดมีพายุลูกใหญ ่เข้ามาอีกก ทำให้การไปเอาเซรุ่มเพื่อกลับมารักษาพวกเด็กๆแทบจะเป ็นไปไม่ได้เลย ความหวังทั้งหมดจึงพุ่งตรงไปที่ Leonhard Seppala (Willem Dafoe) และ สุนัขลากเลื่อนที่ชื่อ Togo ของเขาเพื่อการเดินทางเร็วที่สุดเท่าที่จะทำได้
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